Distarch phosphate was tested for acute toxicity in mice, rats, guinea pigs, rabbits, and cats. The tests showed LD50 values of 7 to 35 g/kg bw, depending on the species, but no deaths occurred. The livers and kidneys of some animals showed no abnormality related to the modified starch. The available data suggests that the LD50 values for distarch phosphate were all above 7 g/kg bw.
No data on the acute oral toxicity of oxidised starch (E 1404), monostarch phosphate (E 1410), phosphated distarch phosphate (E 1413), acetylated distarch phosphate (E 1414), acetylated starch (E 1420), acetylated distarch adipate (E 1422), hydroxypropyl starch (E 1440), hydroxypropyl starch phosphate (E 1442), starch sodium octenyl succinate (E 1450), acetylated oxidised starch (E 1451) and starch aluminium octenyl succinate (E 1452) were available.